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Association between cytokine levels, sepsis severity and clinical outcomes in sepsis: a quantitative systematic review protocol

INTRODUCTION: It is widely assumed that sepsis is a life-threatening systemic inflammation caused by a dysregulated host response to infection mediated by an increase in multiple proinflammatory cytokines. The levels of key proinflammatory cytokines tumour necrosis factor, interleukin-1β and interfe...

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Autores principales: Gharamti, Amal, Samara, Omar, Monzon, Anthony, Scherger, Sias, DeSanto, Kristen, Sillau, Stefan, Franco-Paredes, Carlos, Henao-Martínez, Andrés, Shapiro, Leland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354287/
https://www.ncbi.nlm.nih.gov/pubmed/34373304
http://dx.doi.org/10.1136/bmjopen-2020-048476
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author Gharamti, Amal
Samara, Omar
Monzon, Anthony
Scherger, Sias
DeSanto, Kristen
Sillau, Stefan
Franco-Paredes, Carlos
Henao-Martínez, Andrés
Shapiro, Leland
author_facet Gharamti, Amal
Samara, Omar
Monzon, Anthony
Scherger, Sias
DeSanto, Kristen
Sillau, Stefan
Franco-Paredes, Carlos
Henao-Martínez, Andrés
Shapiro, Leland
author_sort Gharamti, Amal
collection PubMed
description INTRODUCTION: It is widely assumed that sepsis is a life-threatening systemic inflammation caused by a dysregulated host response to infection mediated by an increase in multiple proinflammatory cytokines. The levels of key proinflammatory cytokines tumour necrosis factor, interleukin-1β and interferon γ are poorly characterised during sepsis. We believe this project will produce a ‘gold-standard’ document to which other reports on cytokine levels will be compared. The objective of this systematic review will be to identify key cytokine circulating levels in patients with sepsis and assess the association between these levels and morbidity and mortality outcomes related to sepsis. METHODS AND ANALYSIS: We would include reports of any design except for case reports. Sepsis patients will comprise those with a diagnosis of sepsis, severe sepsis or septic shock. The primary exposure is levels of three proinflammatory cytokines. The primary outcome is mortality at 28 or 30 days. Study subjects can be of any age, sex or ethnicity. Studies will be restricted to the English language. Medline, Embase, Cochrane Library and Web of Science Core Collection will be searched for eligible studies. A database search will include studies from 1985 to May 2020. Two reviewers will independently screen and select studies, assess methodological quality and extract data. A meta-analysis will be performed, if possible, and the Grading of Recommendations Assessment Development and Evaluation Summary of Findings presented. ETHICS AND DISSEMINATION: Formal ethical approval is not required as data will be extracted from existing literature. This systematic review will be disseminated through a peer-reviewed publication and at conference meetings. PROSPERO REGISTRATION NUMBER: CRD42020179800.
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spelling pubmed-83542872021-08-24 Association between cytokine levels, sepsis severity and clinical outcomes in sepsis: a quantitative systematic review protocol Gharamti, Amal Samara, Omar Monzon, Anthony Scherger, Sias DeSanto, Kristen Sillau, Stefan Franco-Paredes, Carlos Henao-Martínez, Andrés Shapiro, Leland BMJ Open Infectious Diseases INTRODUCTION: It is widely assumed that sepsis is a life-threatening systemic inflammation caused by a dysregulated host response to infection mediated by an increase in multiple proinflammatory cytokines. The levels of key proinflammatory cytokines tumour necrosis factor, interleukin-1β and interferon γ are poorly characterised during sepsis. We believe this project will produce a ‘gold-standard’ document to which other reports on cytokine levels will be compared. The objective of this systematic review will be to identify key cytokine circulating levels in patients with sepsis and assess the association between these levels and morbidity and mortality outcomes related to sepsis. METHODS AND ANALYSIS: We would include reports of any design except for case reports. Sepsis patients will comprise those with a diagnosis of sepsis, severe sepsis or septic shock. The primary exposure is levels of three proinflammatory cytokines. The primary outcome is mortality at 28 or 30 days. Study subjects can be of any age, sex or ethnicity. Studies will be restricted to the English language. Medline, Embase, Cochrane Library and Web of Science Core Collection will be searched for eligible studies. A database search will include studies from 1985 to May 2020. Two reviewers will independently screen and select studies, assess methodological quality and extract data. A meta-analysis will be performed, if possible, and the Grading of Recommendations Assessment Development and Evaluation Summary of Findings presented. ETHICS AND DISSEMINATION: Formal ethical approval is not required as data will be extracted from existing literature. This systematic review will be disseminated through a peer-reviewed publication and at conference meetings. PROSPERO REGISTRATION NUMBER: CRD42020179800. BMJ Publishing Group 2021-08-09 /pmc/articles/PMC8354287/ /pubmed/34373304 http://dx.doi.org/10.1136/bmjopen-2020-048476 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Infectious Diseases
Gharamti, Amal
Samara, Omar
Monzon, Anthony
Scherger, Sias
DeSanto, Kristen
Sillau, Stefan
Franco-Paredes, Carlos
Henao-Martínez, Andrés
Shapiro, Leland
Association between cytokine levels, sepsis severity and clinical outcomes in sepsis: a quantitative systematic review protocol
title Association between cytokine levels, sepsis severity and clinical outcomes in sepsis: a quantitative systematic review protocol
title_full Association between cytokine levels, sepsis severity and clinical outcomes in sepsis: a quantitative systematic review protocol
title_fullStr Association between cytokine levels, sepsis severity and clinical outcomes in sepsis: a quantitative systematic review protocol
title_full_unstemmed Association between cytokine levels, sepsis severity and clinical outcomes in sepsis: a quantitative systematic review protocol
title_short Association between cytokine levels, sepsis severity and clinical outcomes in sepsis: a quantitative systematic review protocol
title_sort association between cytokine levels, sepsis severity and clinical outcomes in sepsis: a quantitative systematic review protocol
topic Infectious Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354287/
https://www.ncbi.nlm.nih.gov/pubmed/34373304
http://dx.doi.org/10.1136/bmjopen-2020-048476
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