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Insights into substrate recognition and specificity for IgG by Endoglycosidase S2
Antibodies bind foreign antigens with high affinity and specificity leading to their neutralization and/or clearance by the immune system. The conserved N-glycan on IgG has significant impact on antibody effector function, with the endoglycosidases of Streptococcus pyogenes deglycosylating the IgG t...
Autores principales: | Aytenfisu, Asaminew H., Deredge, Daniel, Klontz, Erik H., Du, Jonathan, Sundberg, Eric J., MacKerell, Alexander D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354483/ https://www.ncbi.nlm.nih.gov/pubmed/34310592 http://dx.doi.org/10.1371/journal.pcbi.1009103 |
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