Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini

Small tandem duplications of DNA occur frequently in the human genome and are implicated in the aetiology of certain human cancers. Recent studies have suggested that DNA double-strand breaks are causal to this mutational class, but the underlying mechanism remains elusive. Here, we identify a cruci...

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Detalles Bibliográficos
Autores principales: Schimmel, Joost, Muñoz-Subirana, Núria, Kool, Hanneke, van Schendel, Robin, Tijsterman, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355091/
https://www.ncbi.nlm.nih.gov/pubmed/34376693
http://dx.doi.org/10.1038/s41467-021-25154-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355091/
https://www.ncbi.nlm.nih.gov/pubmed/34376693
http://dx.doi.org/10.1038/s41467-021-25154-w

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