Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis

Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the bioenergetic sensor AMPK during glutamoptosis is not defined yet. Here, we show that AMPK rea...

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Detalles Bibliográficos
Autores principales: Bodineau, Clément, Tomé, Mercedes, Courtois, Sarah, Costa, Ana S. H., Sciacovelli, Marco, Rousseau, Benoit, Richard, Elodie, Vacher, Pierre, Parejo-Pérez, Carlos, Bessede, Emilie, Varon, Christine, Soubeyran, Pierre, Frezza, Christian, Murdoch, Piedad del Socorro, Villar, Victor H., Durán, Raúl V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355106/
https://www.ncbi.nlm.nih.gov/pubmed/34376668
http://dx.doi.org/10.1038/s41467-021-25079-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355106/
https://www.ncbi.nlm.nih.gov/pubmed/34376668
http://dx.doi.org/10.1038/s41467-021-25079-4

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