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Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the bioenergetic sensor AMPK during glutamoptosis is not defined yet. Here, we show that AMPK rea...
Autores principales: | Bodineau, Clément, Tomé, Mercedes, Courtois, Sarah, Costa, Ana S. H., Sciacovelli, Marco, Rousseau, Benoit, Richard, Elodie, Vacher, Pierre, Parejo-Pérez, Carlos, Bessede, Emilie, Varon, Christine, Soubeyran, Pierre, Frezza, Christian, Murdoch, Piedad del Socorro, Villar, Victor H., Durán, Raúl V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355106/ https://www.ncbi.nlm.nih.gov/pubmed/34376668 http://dx.doi.org/10.1038/s41467-021-25079-4 |
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