A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity

Malate dehydrogenases (MDHs) sustain tumor growth and carbon metabolism by pathogens including Plasmodium falciparum. However, clinical success of MDH inhibitors is absent, as current small molecule approaches targeting the active site are unselective. The presence of an allosteric binding site at o...

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Detalles Bibliográficos
Autores principales: Reyes Romero, Atilio, Lunev, Serjey, Popowicz, Grzegorz M., Calderone, Vito, Gentili, Matteo, Sattler, Michael, Plewka, Jacek, Taube, Michał, Kozak, Maciej, Holak, Tad A., Dömling, Alexander S. S., Groves, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355244/
https://www.ncbi.nlm.nih.gov/pubmed/34376783
http://dx.doi.org/10.1038/s42003-021-02442-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355244/
https://www.ncbi.nlm.nih.gov/pubmed/34376783
http://dx.doi.org/10.1038/s42003-021-02442-1

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