NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation

Loss-of-function mutations in NEK1 gene, which encodes a serine/threonine kinase, are involved in human developmental disorders and ALS. Here we show that NEK1 regulates retromer-mediated endosomal trafficking by phosphorylating VPS26B. NEK1 deficiency disrupts endosomal trafficking of plasma membra...

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Detalles Bibliográficos
Autores principales: Wang, Huibing, Qi, Weiwei, Zou, Chengyu, Xie, Zhangdan, Zhang, Mengmeng, Naito, Masanori Gomi, Mifflin, Lauren, Liu, Zhen, Najafov, Ayaz, Pan, Heling, Shan, Bing, Li, Ying, Zhu, Zheng-Jiang, Yuan, Junying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355301/
https://www.ncbi.nlm.nih.gov/pubmed/34376696
http://dx.doi.org/10.1038/s41467-021-25157-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355301/
https://www.ncbi.nlm.nih.gov/pubmed/34376696
http://dx.doi.org/10.1038/s41467-021-25157-7

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