Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis

Resolution advances in cryoelectron microscopy (cryo-EM) now offer the possibility to visualize structural effects of naturally occurring resistance mutations in proteins and also of understanding the binding mechanisms of small drug molecules. In Mycobacterium tuberculosis the multifunctional heme...

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Detalles Bibliográficos
Autores principales: Munir, Asma, Wilson, Michael T., Hardwick, Steven W., Chirgadze, Dimitri Y., Worrall, Jonathan A.R., Blundell, Tom L., Chaplin, Amanda K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355310/
https://www.ncbi.nlm.nih.gov/pubmed/33444527
http://dx.doi.org/10.1016/j.str.2020.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355310/
https://www.ncbi.nlm.nih.gov/pubmed/33444527
http://dx.doi.org/10.1016/j.str.2020.12.008

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