Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs

B lymphocytes are exquisitely sensitive to fluctuations in nutrient signaling by the Rag GTPases, and 15% of follicular lymphomas (FLs) harbor activating mutations in RRAGC. Hence, a potential therapeutic approach against malignant B cells is to inhibit Rag GTPase signaling, but because such inhibit...

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Detalles Bibliográficos
Autores principales: Ortega-Molina, Ana, Lebrero-Fernández, Cristina, Sanz, Alba, Deleyto-Seldas, Nerea, Plata-Gómez, Ana Belén, Menéndez, Camino, Graña-Castro, Osvaldo, Caleiras, Eduardo, Efeyan, Alejo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355512/
https://www.ncbi.nlm.nih.gov/pubmed/34260908
http://dx.doi.org/10.1016/j.celrep.2021.109372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355512/
https://www.ncbi.nlm.nih.gov/pubmed/34260908
http://dx.doi.org/10.1016/j.celrep.2021.109372

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