Gasdermin D Mediates Inflammation-Induced Defects in Reverse Cholesterol Transport and Promotes Atherosclerosis

Activation of inflammasomes, such as Nlrp3 and AIM2, can exacerbate atherosclerosis in mice and humans. Gasdermin D (GsdmD) serves as a final executor of inflammasome activity, by generating membrane pores for the release of mature Interleukin-1beta (IL-1β). Inflammation dampens reverse cholesterol...

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Detalles Bibliográficos
Autores principales: Opoku, Emmanuel, Traughber, Cynthia Alicia, Zhang, David, Iacano, Amanda J., Khan, Mariam, Han, Juying, Smith, Jonathan D., Gulshan, Kailash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355565/
https://www.ncbi.nlm.nih.gov/pubmed/34395445
http://dx.doi.org/10.3389/fcell.2021.715211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355565/
https://www.ncbi.nlm.nih.gov/pubmed/34395445
http://dx.doi.org/10.3389/fcell.2021.715211

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