Iterative single-cell multi-omic integration using online learning

Integrating large single-cell gene expression, chromatin accessibility and DNA methylation datasets requires general and scalable computational approaches. Here we describe online integrative nonnegative matrix factorization (iNMF), an algorithm for integrating large, diverse, and continually arrivi...

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Detalles Bibliográficos
Autores principales: Gao, Chao, Liu, Jialin, Kriebel, April R., Preissl, Sebastian, Luo, Chongyuan, Castanon, Rosa, Sandoval, Justin, Rivkin, Angeline, Nery, Joseph R., Behrens, Margarita M., Ecker, Joseph R., Ren, Bing, Welch, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355612/
https://www.ncbi.nlm.nih.gov/pubmed/33875866
http://dx.doi.org/10.1038/s41587-021-00867-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355612/
https://www.ncbi.nlm.nih.gov/pubmed/33875866
http://dx.doi.org/10.1038/s41587-021-00867-x

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