Antimelanoma activities of chimeric thiazole–androstenone derivatives

The discovery of chimeric anti-melanoma agents is reported. These molecules are potent growth suppressors of melanoma cells in vitro with growth inhibition of 50% (GI(50)) values as low as 1.32 µM. Compounds were more toxic to melanoma cells in vitro than commonly used anti-melanoma agent dacarbazin...

Descripción completa

Detalles Bibliográficos
Autores principales: Chambers, Steven A., Newman, Mathew, Frangie, Melissa M., Savenka, Alena V., Basnakian, Alexei. G., Alam, Mohammad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355692/
https://www.ncbi.nlm.nih.gov/pubmed/34430045
http://dx.doi.org/10.1098/rsos.210395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355692/
https://www.ncbi.nlm.nih.gov/pubmed/34430045
http://dx.doi.org/10.1098/rsos.210395

Ejemplares similares