Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer’s Disease

Silence information regulator 3 (SIRT3) is an NAD(+) dependent deacetylase enzyme that enhances the function of key mitochondrial proteins. We have earlier demonstrated that deletion of Sirt3 gene leads to downregulation of metabolic enzymes, mitochondrial dysfunction and neuroinflammation in the br...

Descripción completa

Detalles Bibliográficos
Autores principales: Tyagi, Alpna, Mirita, Carol, Shah, Iman, Reddy, P. Hemachandra, Pugazhenthi, Subbiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355826/
https://www.ncbi.nlm.nih.gov/pubmed/34393764
http://dx.doi.org/10.3389/fnagi.2021.716616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355826/
https://www.ncbi.nlm.nih.gov/pubmed/34393764
http://dx.doi.org/10.3389/fnagi.2021.716616

Ejemplares similares