Guardian of the Genome: An Alternative RAG/Transib Co-Evolution Hypothesis for the Origin of V(D)J Recombination

The appearance of adaptive immunity in jawed vertebrates is termed the immunological ‘Big Bang’ because of the short evolutionary time over which it developed. Underlying it is the recombination activating gene (RAG)-based V(D)J recombination system, which initiates the sequence diversification of t...

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Detalles Bibliográficos
Autores principales: Yakovenko, Iryna, Agronin, Jacob, Smith, L. Courtney, Oren, Matan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355894/
https://www.ncbi.nlm.nih.gov/pubmed/34394111
http://dx.doi.org/10.3389/fimmu.2021.709165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355894/
https://www.ncbi.nlm.nih.gov/pubmed/34394111
http://dx.doi.org/10.3389/fimmu.2021.709165

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