BRCA2 deficiency reveals that oxidative stress impairs RNaseH1 function to cripple mitochondrial DNA maintenance

Oxidative stress is a ubiquitous cellular challenge implicated in aging, neurodegeneration, and cancer. By studying pathogenic mutations in the tumor suppressor BRCA2, we identify a general mechanism by which oxidative stress restricts mitochondrial (mt)DNA replication. BRCA2 inactivation induces R-...

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Detalles Bibliográficos
Autores principales: Renaudin, Xavier, Lee, Miyoung, Shehata, Mona, Surmann, Eva-Maria, Venkitaraman, Ashok R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356021/
https://www.ncbi.nlm.nih.gov/pubmed/34348152
http://dx.doi.org/10.1016/j.celrep.2021.109478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356021/
https://www.ncbi.nlm.nih.gov/pubmed/34348152
http://dx.doi.org/10.1016/j.celrep.2021.109478

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