Developing PspCas13b-based enhanced RESCUE system, eRESCUE, with efficient RNA base editing

RNA base editing is potential for cellular function research and genetic diseases treating. There are two main RNA base editors, REPAIR and RESCUE, for in vitro use. REPAIR was developed by fusing inactivated Cas13 (dCas13) with the adenine deaminase domain of ADAR2, which efficiently performs adeno...

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Detalles Bibliográficos
Autores principales: Li, Guo, Wang, Yihan, Li, Xiangyang, Wang, Yuzhe, Huang, Xingxu, Gao, Jianen, Hu, Xiaoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356384/
https://www.ncbi.nlm.nih.gov/pubmed/34380502
http://dx.doi.org/10.1186/s12964-021-00716-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356384/
https://www.ncbi.nlm.nih.gov/pubmed/34380502
http://dx.doi.org/10.1186/s12964-021-00716-z

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