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Developing PspCas13b-based enhanced RESCUE system, eRESCUE, with efficient RNA base editing
RNA base editing is potential for cellular function research and genetic diseases treating. There are two main RNA base editors, REPAIR and RESCUE, for in vitro use. REPAIR was developed by fusing inactivated Cas13 (dCas13) with the adenine deaminase domain of ADAR2, which efficiently performs adeno...
Autores principales: | Li, Guo, Wang, Yihan, Li, Xiangyang, Wang, Yuzhe, Huang, Xingxu, Gao, Jianen, Hu, Xiaoxiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356384/ https://www.ncbi.nlm.nih.gov/pubmed/34380502 http://dx.doi.org/10.1186/s12964-021-00716-z |
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