Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors

BACKGROUND: Tumor response to therapy is affected by both the cell types and the cell states present in the tumor microenvironment. This is true for many cancer treatments, including immune checkpoint inhibitors (ICIs). While it is well-established that ICIs promote T cell activation, their broader...

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Detalles Bibliográficos
Autores principales: Davis-Marcisak, Emily F., Fitzgerald, Allison A., Kessler, Michael D., Danilova, Ludmila, Jaffee, Elizabeth M., Zaidi, Neeha, Weiner, Louis M., Fertig, Elana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356429/
https://www.ncbi.nlm.nih.gov/pubmed/34376232
http://dx.doi.org/10.1186/s13073-021-00944-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356429/
https://www.ncbi.nlm.nih.gov/pubmed/34376232
http://dx.doi.org/10.1186/s13073-021-00944-5

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