Cargando…

Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic β-cell dedifferentiation

BACKGROUND: Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating type 2 diabetes mellitus (T2DM) in clinical studies. Accumulating evidence has suggested that the therapeutic effects of MSCs are not due to their direct differentiation into functional β-cells but are instead...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Qin, Song, Jia, Cui, Chen, Wang, Jinbang, Hu, Huiqing, Guo, Xinghong, Yang, Mengmeng, Wang, Lingshu, Yan, Fei, Liang, Kai, Liu, Zhaojian, Liu, Fuqiang, Sun, Zheng, Dong, Ming, Hou, Xinguo, Chen, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356465/ https://www.ncbi.nlm.nih.gov/pubmed/34380570 http://dx.doi.org/10.1186/s13287-021-02371-0

Ejemplares similares

Retraction Note: Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic β-cell dedifferentiation
por: He, Qin, et al.
Publicado: (2022)

Mesenchymal stromal cells ameliorate diabetes‐induced muscle atrophy through exosomes by enhancing AMPK/ULK1‐mediated autophagy
por: Song, Jia, et al.
Publicado: (2023)

Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy
por: He, Qin, et al.
Publicado: (2020)

Retraction Note: Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy
por: He, Qin, et al.
Publicado: (2022)

Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a
por: Cheng, Qian, et al.
Publicado: (2017)

Mesenchymal stromal cells ameliorate oxidative stress-induced islet endothelium apoptosis and functional impairment via Wnt4-β-catenin signaling
por: Wang, Lingshu, et al.
Publicado: (2017)

cGAS-STING activation contributes to podocyte injury in diabetic kidney disease
por: Zang, Nan, et al.
Publicado: (2022)

Mesenchymal stem cells ameliorate β cell dysfunction of human type 2 diabetic islets by reversing β cell dedifferentiation
por: Wang, Le, et al.
Publicado: (2020)

Circulating Exosomes Derived-miR-146a from Systemic Lupus Erythematosus Patients Regulates Senescence of Mesenchymal Stem Cells
por: Dong, Chen, et al.
Publicado: (2019)

Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells
por: Wang, Fang, et al.
Publicado: (2022)

MiR146a modulates chondrogenesis of bone marrow mesenchymal stem cells by modulating Lsm11 expression
por: Liu, Yuhang, et al.
Publicado: (2023)

Exosomal miR‐128‐3p reversed fibrinogen‐mediated inhibition of oligodendrocyte progenitor cell differentiation and remyelination after cerebral ischemia
por: Hou, Huiqing, et al.
Publicado: (2023)

Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a
por: Xu, Meiqian, et al.
Publicado: (2021)

Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma
por: Xie, Jiajun, et al.
Publicado: (2021)

Nomogram Predicting the Risk of Progression from Prediabetes to Diabetes After a 3-Year Follow-Up in Chinese Adults
por: Liang, Kai, et al.
Publicado: (2021)

Retracted: Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells
por: and Alternative Medicine, Evidence-Based Complementary
Publicado: (2023)

Poor Control of Plasma Triglycerides Is Associated with Early Decline of Estimated Glomerular Filtration Rates in New-Onset Type 2 Diabetes in China: Results from a 3-Year Follow-Up Study
por: Wang, Chuan, et al.
Publicado: (2020)

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b
por: Cho, Sunglim, et al.
Publicado: (2018)

Exosomes Derived from miR-146a-5p-Enriched Mesenchymal Stem Cells Protect the Cardiomyocytes and Myocardial Tissues in the Polymicrobial Sepsis through Regulating MYBL1
por: Liu, Chun, et al.
Publicado: (2021)

Effects of miR-146a on the osteogenesis of adipose-derived mesenchymal stem cells and bone regeneration
por: Xie, Qing, et al.
Publicado: (2017)

Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance
por: Hu, Y.-B., et al.
Publicado: (2018)

Human cell dedifferentiation in mesenchymal condensates through controlled autophagy
por: Pennock, Rebecca, et al.
Publicado: (2015)

Prognostic and diagnostic potential of miR-146a in oesophageal squamous cell carcinoma
por: Wang, Cong, et al.
Publicado: (2016)

miR-146a-5p mediates epithelial–mesenchymal transition of oesophageal squamous cell carcinoma via targeting Notch2
por: Wang, Cong, et al.
Publicado: (2016)

miR-146a-5p mediates epithelial–mesenchymal transition of oesophageal squamous cell carcinoma via targeting Notch2
por: Wang, Cong, et al.
Publicado: (2018)

Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
por: Son, Jinsook, et al.
Publicado: (2023)

Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression
por: Fan, Cuiqin, et al.
Publicado: (2022)

The roles of mesenchymal stem cell-derived exosomes in diabetes mellitus and its related complications
por: Yang, Mengmeng, et al.
Publicado: (2022)

Correction: Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance
por: Hu, Y.-B., et al.
Publicado: (2019)

miR-146a and miR-146b in the diagnosis and prognosis of papillary thyroid carcinoma
por: Qiu, Zhenwei, et al.
Publicado: (2017)

The Effect of miR-146a on the Gene Expression of Immunoregulatory Cytokines in Human Mesenchymal Stromal Cells
por: Ko, Jung Hwa, et al.
Publicado: (2020)

Dedifferentiated Giant-Cell Tumor of Bone with an Undifferentiated Round Cell Mesenchymal Component
por: Estrada-Villaseñor, Eréndira G., et al.
Publicado: (2014)

miR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells
por: Hsieh, Jui-Yu, et al.
Publicado: (2013)

Urinary exosome miR-146a is a potential marker of albuminuria in essential hypertension
por: Perez-Hernandez, Javier, et al.
Publicado: (2018)

Mesenchymal stem cell-derived exosomal miR-223 regulates neuronal cell apoptosis
por: Wei, Hong, et al.
Publicado: (2020)

miR-146a-5p-mediated suppression on trophoblast cell progression and epithelial-mesenchymal transition in preeclampsia
por: Peng, Pingping, et al.
Publicado: (2021)

Exosomal miR‐1255b‐5p targets human telomerase reverse transcriptase in colorectal cancer cells to suppress epithelial‐to‐mesenchymal transition
por: Zhang, Xue, et al.
Publicado: (2020)

Comparison of CD146 +/− mesenchymal stem cells in improving premature ovarian failure
por: Zhang, Lin, et al.
Publicado: (2022)

Intestinal epithelial plasticity and regeneration via cell dedifferentiation
por: Liu, Yuan, et al.
Publicado: (2020)

CD146(+) mesenchymal stem cells display greater therapeutic potential than CD146(–) cells for treating collagen-induced arthritis in mice
por: Wu, Cheng-Chi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9q2rag87f3hvomrk599ebi8v59