Radical hydroxymethylation of alkyl iodides using formaldehyde as a C1 synthon

Radical hydroxymethylation using formaldehyde as a C1 synthon is challenging due to the reversible and endothermic nature of the addition process. Here we report a strategy that couples alkyl iodide building blocks with formaldehyde through the use of photocatalysis and a phosphine additive. Halogen...

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Detalles Bibliográficos
Autores principales: Caiger, Lewis, Sinton, Conar, Constantin, Timothée, Douglas, James J., Sheikh, Nadeem S., Juliá, Fabio, Leonori, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356745/
https://www.ncbi.nlm.nih.gov/pubmed/34447537
http://dx.doi.org/10.1039/d1sc03083c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356745/
https://www.ncbi.nlm.nih.gov/pubmed/34447537
http://dx.doi.org/10.1039/d1sc03083c

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