Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice

Aging is a risk factor for progressive fibrotic disorders involving diverse organ systems, including the lung. Idiopathic pulmonary fibrosis, an age-associated degenerative lung disorder, is characterized by persistence of apoptosis-resistant myofibroblasts. In this report, we demonstrate that sirtu...

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Detalles Bibliográficos
Autores principales: Rehan, Mohammad, Kurundkar, Deepali, Kurundkar, Ashish R., Logsdon, Naomi J., Smith, Samuel R., Chanda, Diptiman, Bernard, Karen, Sanders, Yan Y., Deshane, Jessy S., Dsouza, Kevin G., Rangarajan, Sunad, Zmijewski, Jaroslaw W., Thannickal, Victor J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357317/
https://www.ncbi.nlm.nih.gov/pubmed/34386777
http://dx.doi.org/10.1038/s43587-021-00027-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357317/
https://www.ncbi.nlm.nih.gov/pubmed/34386777
http://dx.doi.org/10.1038/s43587-021-00027-5

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