Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside

Remdesivir, a monophosphate prodrug of nucleoside analog GS-441524, is widely used for the treatment of moderate to severe COVID-19. It has been suggested to use GS-441524 instead of remdesivir in the clinic and in new inhalation formulations. Thus, we compared the anti-SARS-CoV-2 activity of remdes...

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Detalles Bibliográficos
Autores principales: Tao, Sijia, Zandi, Keivan, Bassit, Leda, Ong, Yee Tsuey, Verma, Kiran, Liu, Peng, Downs-Bowen, Jessica A., McBrayer, Tamara, LeCher, Julia C., Kohler, James J., Tedbury, Philip R., Kim, Baek, Amblard, Franck, Sarafianos, Stefan G., Schinazi, Raymond F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
COVID-19 therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357487/
https://www.ncbi.nlm.nih.gov/pubmed/34870151
http://dx.doi.org/10.1016/j.crphar.2021.100045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357487/
https://www.ncbi.nlm.nih.gov/pubmed/34870151
http://dx.doi.org/10.1016/j.crphar.2021.100045

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