Rewiring of the ubiquitinated proteome determines ageing in C. elegans

Ageing is driven by a loss of cellular integrity(1). Given the major role of ubiquitin modifications in cell function(2), here we assess the link between ubiquitination and ageing by quantifying whole-proteome ubiquitin signatures in Caenorhabditis elegans. We find a remodelling of the ubiquitinated...

Descripción completa

Detalles Bibliográficos
Autores principales: Koyuncu, Seda, Loureiro, Rute, Lee, Hyun Ju, Wagle, Prerana, Krueger, Marcus, Vilchez, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357631/
https://www.ncbi.nlm.nih.gov/pubmed/34321666
http://dx.doi.org/10.1038/s41586-021-03781-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357631/
https://www.ncbi.nlm.nih.gov/pubmed/34321666
http://dx.doi.org/10.1038/s41586-021-03781-z

Ejemplares similares