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Rewiring of the ubiquitinated proteome determines ageing in C. elegans

Ageing is driven by a loss of cellular integrity(1). Given the major role of ubiquitin modifications in cell function(2), here we assess the link between ubiquitination and ageing by quantifying whole-proteome ubiquitin signatures in Caenorhabditis elegans. We find a remodelling of the ubiquitinated...

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Detalles Bibliográficos
Autores principales:	Koyuncu, Seda, Loureiro, Rute, Lee, Hyun Ju, Wagle, Prerana, Krueger, Marcus, Vilchez, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357631/ https://www.ncbi.nlm.nih.gov/pubmed/34321666 http://dx.doi.org/10.1038/s41586-021-03781-z

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