Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and...

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Detalles Bibliográficos
Autores principales: Lee, Jinhee, Jang, Soyoung, Choi, Minjee, Kang, Mincheol, Lim, Su-Geun, Kim, SI-Yong, Jang, Soyeon, Ko, Jiwon, Kim, Eungyung, Yi, Junkoo, Choo, Yeonsik, Kim, Myoung Ok, Ryoo, Zae Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357804/
https://www.ncbi.nlm.nih.gov/pubmed/34381063
http://dx.doi.org/10.1038/s41598-021-94855-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357804/
https://www.ncbi.nlm.nih.gov/pubmed/34381063
http://dx.doi.org/10.1038/s41598-021-94855-5

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