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Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357804/ https://www.ncbi.nlm.nih.gov/pubmed/34381063 http://dx.doi.org/10.1038/s41598-021-94855-5 |
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author | Lee, Jinhee Jang, Soyoung Choi, Minjee Kang, Mincheol Lim, Su-Geun Kim, SI-Yong Jang, Soyeon Ko, Jiwon Kim, Eungyung Yi, Junkoo Choo, Yeonsik Kim, Myoung Ok Ryoo, Zae Young |
author_facet | Lee, Jinhee Jang, Soyoung Choi, Minjee Kang, Mincheol Lim, Su-Geun Kim, SI-Yong Jang, Soyeon Ko, Jiwon Kim, Eungyung Yi, Junkoo Choo, Yeonsik Kim, Myoung Ok Ryoo, Zae Young |
author_sort | Lee, Jinhee |
collection | PubMed |
description | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless of the inducement. Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased monocyte and neutrophil populations in the TG mice. In conclusion, overexpression of CTSS in mice influences TLR7 expression, autoantibodies and IFN-α, which leads to an autoimmune reaction and exacerbates lupus-like symptoms. |
format | Online Article Text |
id | pubmed-8357804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83578042021-08-13 Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice Lee, Jinhee Jang, Soyoung Choi, Minjee Kang, Mincheol Lim, Su-Geun Kim, SI-Yong Jang, Soyeon Ko, Jiwon Kim, Eungyung Yi, Junkoo Choo, Yeonsik Kim, Myoung Ok Ryoo, Zae Young Sci Rep Article Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless of the inducement. Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased monocyte and neutrophil populations in the TG mice. In conclusion, overexpression of CTSS in mice influences TLR7 expression, autoantibodies and IFN-α, which leads to an autoimmune reaction and exacerbates lupus-like symptoms. Nature Publishing Group UK 2021-08-11 /pmc/articles/PMC8357804/ /pubmed/34381063 http://dx.doi.org/10.1038/s41598-021-94855-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lee, Jinhee Jang, Soyoung Choi, Minjee Kang, Mincheol Lim, Su-Geun Kim, SI-Yong Jang, Soyeon Ko, Jiwon Kim, Eungyung Yi, Junkoo Choo, Yeonsik Kim, Myoung Ok Ryoo, Zae Young Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice |
title | Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice |
title_full | Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice |
title_fullStr | Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice |
title_full_unstemmed | Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice |
title_short | Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice |
title_sort | overexpression of cathepsin s exacerbates lupus pathogenesis through upregulation tlr7 and ifn-α in transgenic mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357804/ https://www.ncbi.nlm.nih.gov/pubmed/34381063 http://dx.doi.org/10.1038/s41598-021-94855-5 |
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