Cargando…

Structural basis for Ca(2+) activation of the heteromeric PKD1L3/PKD2L1 channel

The heteromeric complex between PKD1L3, a member of the polycystic kidney disease (PKD) protein family, and PKD2L1, also known as TRPP2 or TRPP3, has been a prototype for mechanistic characterization of heterotetrametric TRP-like channels. Here we show that a truncated PKD1L3/PKD2L1 complex with the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Su, Qiang, Chen, Mengying, Wang, Yan, Li, Bin, Jing, Dan, Zhan, Xiechao, Yu, Yong, Shi, Yigong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357825/ https://www.ncbi.nlm.nih.gov/pubmed/34381056 http://dx.doi.org/10.1038/s41467-021-25216-z

Ejemplares similares

The response of PKD1L3 / PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs
por: Ishii, Sho, et al.
Publicado: (2012)

Pkd1 and Pkd2 Are Required for Normal Placental Development
por: Garcia-Gonzalez, Miguel A., et al.
Publicado: (2010)

Atypical calcium regulation of the PKD2-L1 polycystin ion channel
por: DeCaen, Paul G, et al.
Publicado: (2016)

Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
por: Su, Qiang, et al.
Publicado: (2018)

High Resolution Melt analysis for mutation screening in PKD1 and PKD2
por: Bataille, Stanislas, et al.
Publicado: (2011)

Acid-induced off-response of PKD2L1 channel in Xenopus oocytes and its regulation by Ca(2+)
por: Hussein, Shaimaa, et al.
Publicado: (2015)

The role of calmodulin in regulating calcium-permeable PKD2L1 channel activity
por: Park, Eunice Yon June, et al.
Publicado: (2019)

Identified eleven exon variants in PKD1 and PKD2 genes that altered RNA splicing by minigene assay
por: Liu, Xuyan, et al.
Publicado: (2023)

PKD1 and PKD2 mutations in Slovenian families with autosomal dominant polycystic kidney disease
por: Vouk, Katja, et al.
Publicado: (2006)

A novel PKD2L1 C-terminal domain critical for trimerization and channel function
por: Zheng, Wang, et al.
Publicado: (2015)

Enhanced β-adrenergic response in mice with dominant-negative expression of the PKD2L1 channel
por: Murakami, Manabu, et al.
Publicado: (2022)

Polycystic Kidney Disease Caused by Bilineal Inheritance of Truncating PKD1 as Well as PKD2 Mutations
por: Losekoot, Monique, et al.
Publicado: (2020)

PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression
por: Lakhia, Ronak, et al.
Publicado: (2022)

Identification of novel PKD1 and PKD2 mutations in Korean patients with autosomal dominant polycystic kidney disease
por: Choi, Rihwa, et al.
Publicado: (2014)

PKD1 Compared With PKD2 Genotype and Cardiac Hospitalizations in the Halt Progression of Polycystic Kidney Disease Studies
por: Steele, Cortney, et al.
Publicado: (2021)

Upregulation of PKD1L2 provokes a complex neuromuscular disease in the mouse
por: Mackenzie, Francesca E., et al.
Publicado: (2009)

Identification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease
por: Liu, Bei, et al.
Publicado: (2015)

Prediction of Renal Prognosis in Patients with Autosomal Dominant Polycystic Kidney Disease Using PKD1/PKD2 Mutations
por: Kataoka, Hiroshi, et al.
Publicado: (2020)

p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis
por: Li, Haili, et al.
Publicado: (2019)

Small Interactor of PKD2 (SIP), a novel PKD2-related single-pass transmembrane protein, is required for proteolytic processing and ciliary import of Chlamydomonas PKD2
por: Das, Poulomi, et al.
Publicado: (2023)

Role of PKD2 in Rheotaxis in Dictyostelium
por: Lima, Wanessa C., et al.
Publicado: (2014)

The neural stem cell properties of Pkd2l1(+) cerebrospinal fluid-contacting neurons in vivo
por: Cao, Liang, et al.
Publicado: (2022)

Diagnosis of autosomal dominant polycystic kidney disease using efficient PKD1 and PKD2 targeted next-generation sequencing
por: Trujillano, Daniel, et al.
Publicado: (2014)

Corrigendum: Identification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease
por: Liu, Bei, et al.
Publicado: (2016)

Deciphering Variability of PKD1 and PKD2 in an Italian Cohort of 643 Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)
por: Carrera, Paola, et al.
Publicado: (2016)

Sour Taste Responses in Mice Lacking PKD Channels
por: Horio, Nao, et al.
Publicado: (2011)

Correction: Role of PKD2 in Rheotaxis in Dictyostelium
Publicado: (2014)

Physiological and Behavioral Responses to Optogenetic Stimulation of PKD2L1(+) Type III Taste Cells
por: Wilson, Courtney E., et al.
Publicado: (2019)

Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
por: Sternberg, Jenna R., et al.
Publicado: (2018)

The Neural Stem Cell Properties of PKD2L1(+) Cerebrospinal Fluid-Contacting Neurons in vitro
por: Wang, Shuo, et al.
Publicado: (2021)

FOXA2 controls Pkd1l1 expression in the mouse node during left-right determination
por: Leordean, D, et al.
Publicado: (2015)

Co-Inheritance of Pathogenic Variants in PKD1 and PKD2 Genes Determined by Parental Segregation and De Novo Origin: A Case Report
por: Graziani, Ludovico, et al.
Publicado: (2023)

Bilineal inheritance of pathogenic PKD1 and PKD2 variants in a Czech family with autosomal dominant polycystic kidney disease – a case report
por: Elisakova, Veronika, et al.
Publicado: (2018)

Chromosomal evolution of the PKD1 gene family in primates
por: Kirsch, Stefan, et al.
Publicado: (2008)

Chromosomal evolution of the PKD1 gene family in primates
por: Kirsch, Stefan, et al.
Publicado: (2009)

Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella
por: Huang, Kaiyao, et al.
Publicado: (2007)

sy680 is a novel allele of pkd-2
por: Whittaker, Allyson, et al.
Publicado: (2017)

Role of PKD2 in the endoplasmic reticulum calcium homeostasis
por: Liu, Xiong, et al.
Publicado: (2022)

The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation
por: Shimizu, Takahiro, et al.
Publicado: (2017)

Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure
por: Bulley, Simon, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lv927vhiscdq3k2jh2poimk20o