The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model

Spreading of aggregate pathology across brain regions acts as a driver of disease progression in Tau-related neurodegeneration, including Alzheimer’s disease (AD) and frontotemporal dementia. Aggregate seeds released from affected cells are internalized by naïve cells and induce the prion-like templ...

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Detalles Bibliográficos
Autores principales: Yuste-Checa, Patricia, Trinkaus, Victoria A., Riera-Tur, Irene, Imamoglu, Rahmi, Schaller, Theresa F., Wang, Huping, Dudanova, Irina, Hipp, Mark S., Bracher, Andreas, Hartl, F. Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357826/
https://www.ncbi.nlm.nih.gov/pubmed/34381050
http://dx.doi.org/10.1038/s41467-021-25060-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357826/
https://www.ncbi.nlm.nih.gov/pubmed/34381050
http://dx.doi.org/10.1038/s41467-021-25060-1

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