Hyperglycaemia up-regulates placental growth factor (PlGF) expression and secretion in endothelial cells via suppression of PI3 kinase-Akt signalling and activation of FOXO1

Placenta growth factor (PlGF) is a pro-inflammatory angiogenic mediator that promotes many pathologies including diabetic complications and atherosclerosis. Widespread endothelial dysfunction precedes the onset of these conditions. As very little is known of the mechanism(s) controlling PlGF express...

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Detalles Bibliográficos
Autores principales: Sissaoui, Samir, Egginton, Stuart, Ting, Ling, Ahmed, Asif, Hewett, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357836/
https://www.ncbi.nlm.nih.gov/pubmed/34381074
http://dx.doi.org/10.1038/s41598-021-95511-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357836/
https://www.ncbi.nlm.nih.gov/pubmed/34381074
http://dx.doi.org/10.1038/s41598-021-95511-8

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