Cargando…

Hyperglycaemia up-regulates placental growth factor (PlGF) expression and secretion in endothelial cells via suppression of PI3 kinase-Akt signalling and activation of FOXO1

Placenta growth factor (PlGF) is a pro-inflammatory angiogenic mediator that promotes many pathologies including diabetic complications and atherosclerosis. Widespread endothelial dysfunction precedes the onset of these conditions. As very little is known of the mechanism(s) controlling PlGF express...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sissaoui, Samir, Egginton, Stuart, Ting, Ling, Ahmed, Asif, Hewett, Peter W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357836/ https://www.ncbi.nlm.nih.gov/pubmed/34381074 http://dx.doi.org/10.1038/s41598-021-95511-8

Ejemplares similares

PlGF, immune system and hypertension
por: Carnevale, Daniela, et al.
Publicado: (2015)

PlGF Immunological Impact during Pregnancy
por: Albonici, Loredana, et al.
Publicado: (2020)

Accurate Prediction of Total PlGF (Placental Growth Factor) From Free PlGF and sFlt-1 (Soluble Fms-Like Tyrosine Kinase-1): Evidence for Markedly Elevated PlGF Levels in Women With Acute Fatty Liver of Pregnancy
por: Neuman, Rugina I., et al.
Publicado: (2021)

Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus
por: Nuzzo, Anna Maria, et al.
Publicado: (2021)

A comparison of the diagnostic utility of the sFlt-1/PlGF ratio versus PlGF alone for the detection of preeclampsia/HELLP syndrome
por: Stepan, H., et al.
Publicado: (2016)

Difference of concentration of placental soluble fms-like tyrosine kinase-1(sFlt-1), placental growth factor (PlGF), and sFlt-1/PlGF ratio in severe preeclampsia and normal pregnancy
por: Gurnadi, Jeffry Iman, et al.
Publicado: (2015)

Multifaceted Role of the Placental Growth Factor (PlGF) in the Antitumor Immune Response and Cancer Progression
por: Albonici, Loredana, et al.
Publicado: (2019)

sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies—A Review of the Literature
por: Sapantzoglou, Ioakeim, et al.
Publicado: (2023)

Changes in concentrations of melatonin, PlGF, and cytokines in women with preeclampsia
por: Savka, Ruslan Florovych, et al.
Publicado: (2023)

Inhibition of Stromal PlGF Suppresses the Growth of Prostate Cancer Xenografts
por: Zins, Karin, et al.
Publicado: (2013)

Efficiency of sFlt-1/PlGF Ratio in Preeclampsia Diagnosis
por: Tataru-Copos, Anca-Florina, et al.
Publicado: (2022)

Reduced expression in preterm birth of sFLT-1 and PlGF with a high sFLT-1/PlGF ratio in extracellular vesicles suggests a potential biomarker
por: Hussein, Sama, et al.
Publicado: (2022)

Lower S-adenosylmethionine levels and DNA hypomethylation of placental growth factor (PlGF) in placental tissue of early-onset preeclampsia-complicated pregnancies
por: Heil, Sandra G., et al.
Publicado: (2019)

Soluble Flt-1 and PlGF: New Markers of Early Pregnancy Loss?
por: Muttukrishna, Shanthi, et al.
Publicado: (2011)

Concentrations of VEGF and PlGF Decrease in Eyes After Intravitreal Conbercept Injection
por: Zhou, Jun, et al.
Publicado: (2018)

Physical activity differentially regulates VEGF, PlGF, and their receptors in the human placenta
por: Bhattacharjee, Jayonta, et al.
Publicado: (2021)

PlGF Reduction Compromises Angiogenesis in Diabetic Foot Disease Through Macrophages
por: Zhu, Lingyan, et al.
Publicado: (2021)

Correlation of sFlt/PlGF ratio with severity of preeclampsia in an Indian population
por: Kumar, Namrata, et al.
Publicado: (2023)

Time-specific placental growth factor (PlGF) across pregnancy and infant birth weight in women with preexisting diabetes
por: James-Todd, Tamarra, et al.
Publicado: (2016)

Perspectives on the Use of Placental Growth Factor (PlGF) in the Prediction and Diagnosis of Pre-Eclampsia: Recent Insights and Future Steps
por: Creswell, Lyndsay, et al.
Publicado: (2023)

PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysema
por: Hou, Hsin-Han, et al.
Publicado: (2014)

Expression of Livin and PlGF in human osteosarcoma is associated with tumor progression and clinical outcome
por: Sun, Kuo, et al.
Publicado: (2018)

Serum PlGF and EGF are independent prognostic markers in non-metastatic colorectal cancer
por: Schölch, Sebastian, et al.
Publicado: (2019)

Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia
por: Nikuei, Pooneh, et al.
Publicado: (2020)

The sFlt-1/PlGF Ratio in Pregnant Patients Affected by COVID-19
por: Kosinska-Kaczynska, Katarzyna, et al.
Publicado: (2023)

Evaluation of Angiogenic Factors (PlGF and sFlt-1) in Pre-eclampsia Diagnosis
por: Sá, Catherine Primo Nogueira de, et al.
Publicado: (2020)

Placental growth factor (PlGF) enhances breast cancer cell motility by mobilising ERK1/2 phosphorylation and cytoskeletal rearrangement
por: Taylor, A P, et al.
Publicado: (2010)

Placental Growth Factor (PlGF) in Women with Suspected Pre-Eclampsia Prior to 35 Weeks’ Gestation: A Budget Impact Analysis
por: Duckworth, Suzy, et al.
Publicado: (2016)

Prediction of Adverse Pregnancy Outcome Related to Placental Dysfunction Using the sFlt-1/PlGF Ratio: A Narrative Review
por: Graupner, Oliver, et al.
Publicado: (2021)

Increased sFlt-1 to PlGF Ratio in Women Who Subsequently Develop Preeclampsia
por: Kim, Shin-Young, et al.
Publicado: (2007)

sFlt‐1/PlGF ratio test for pre‐eclampsia: an economic assessment for the UK
por: Vatish, M., et al.
Publicado: (2016)

Gestational diabetes modifies the association between PlGF in early pregnancy and preeclampsia in women with obesity
por: Vieira, Matias C., et al.
Publicado: (2018)

Proteomics reveals ablation of PlGF increases antioxidant and neuroprotective proteins in the diabetic mouse retina
por: Saddala, Madhu Sudhana, et al.
Publicado: (2018)

Human Placental NADPH Oxidase Mediates sFlt-1 and PlGF Secretion in Early Pregnancy: Exploration of the TGF-β1/p38 MAPK Pathways
por: Hernandez, Isabelle, et al.
Publicado: (2021)

Economic assessment of the use of the sFlt-1/PlGF ratio test to predict preeclampsia in Germany
por: Schlembach, Dietmar, et al.
Publicado: (2018)

Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells
por: Kleiner, Jana, et al.
Publicado: (2018)

Influence of the sFlt-1/PlGF Ratio on Clinical Decision-Making in Women with Suspected Preeclampsia
por: Klein, Evelyn, et al.
Publicado: (2016)

sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19
por: Soldavini, Chiara Maria, et al.
Publicado: (2022)

sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy
por: Kozłowski, Szymon, et al.
Publicado: (2021)

The Impact of Increased Maternal sFlt-1/PlGF Ratio on Motor Outcome of Preterm Infants
por: Middendorf, Lisa, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1c4ir6u0sbe2c8le9co1a4ihsp