The switch of DNA states filtering the extrinsic noise in the system of frequency modulation

There is a special node, which the large noise of the upstream element may not always lead to a broad distribution of downstream elements. This node is DNA, with upstream element TF and downstream elements mRNA and proteins. By applying the stochastic simulation algorithm (SSA) on gene circuits insp...

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Autores principales: Lo, Shih-Chiang, You, Chao-Xuan, Chen, Bo-Ren, Hsieh, Ching-Chu, Li, Cheng-En, Shu, Che-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357933/
https://www.ncbi.nlm.nih.gov/pubmed/34381062
http://dx.doi.org/10.1038/s41598-021-95365-0
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author Lo, Shih-Chiang
You, Chao-Xuan
Chen, Bo-Ren
Hsieh, Ching-Chu
Li, Cheng-En
Shu, Che-Chi
author_facet Lo, Shih-Chiang
You, Chao-Xuan
Chen, Bo-Ren
Hsieh, Ching-Chu
Li, Cheng-En
Shu, Che-Chi
author_sort Lo, Shih-Chiang
collection PubMed
description There is a special node, which the large noise of the upstream element may not always lead to a broad distribution of downstream elements. This node is DNA, with upstream element TF and downstream elements mRNA and proteins. By applying the stochastic simulation algorithm (SSA) on gene circuits inspired by the fim operon in Escherichia coli, we found that cells exchanged the distribution of the upstream transcription factor (TF) for the transitional frequency of DNA. Then cells do an inverse transform, which exchanges the transitional frequency of DNA for the distribution of downstream products. Due to this special feature, DNA in the system of frequency modulation is able to reset the noise. By probability generating function, we know the ranges of parameter values that grant such an interesting phenomenon.
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spelling pubmed-83579332021-08-13 The switch of DNA states filtering the extrinsic noise in the system of frequency modulation Lo, Shih-Chiang You, Chao-Xuan Chen, Bo-Ren Hsieh, Ching-Chu Li, Cheng-En Shu, Che-Chi Sci Rep Article There is a special node, which the large noise of the upstream element may not always lead to a broad distribution of downstream elements. This node is DNA, with upstream element TF and downstream elements mRNA and proteins. By applying the stochastic simulation algorithm (SSA) on gene circuits inspired by the fim operon in Escherichia coli, we found that cells exchanged the distribution of the upstream transcription factor (TF) for the transitional frequency of DNA. Then cells do an inverse transform, which exchanges the transitional frequency of DNA for the distribution of downstream products. Due to this special feature, DNA in the system of frequency modulation is able to reset the noise. By probability generating function, we know the ranges of parameter values that grant such an interesting phenomenon. Nature Publishing Group UK 2021-08-11 /pmc/articles/PMC8357933/ /pubmed/34381062 http://dx.doi.org/10.1038/s41598-021-95365-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lo, Shih-Chiang
You, Chao-Xuan
Chen, Bo-Ren
Hsieh, Ching-Chu
Li, Cheng-En
Shu, Che-Chi
The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
title The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
title_full The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
title_fullStr The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
title_full_unstemmed The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
title_short The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
title_sort switch of dna states filtering the extrinsic noise in the system of frequency modulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357933/
https://www.ncbi.nlm.nih.gov/pubmed/34381062
http://dx.doi.org/10.1038/s41598-021-95365-0
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