ATF6 is required for efficient rhodopsin clearance and retinal homeostasis in the P23H rho retinitis pigmentosa mouse model

Retinitis Pigmentosa (RP) is a blinding disease that arises from loss of rods and subsequently cones. The P23H rhodopsin knock-in (P23H-KI) mouse develops retinal degeneration that mirrors RP phenotype in patients carrying the orthologous variant. Previously, we found that the P23H rhodopsin protein...

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Detalles Bibliográficos
Autores principales: Lee, Eun-Jin, Chan, Priscilla, Chea, Leon, Kim, Kyle, Kaufman, Randal J., Lin, Jonathan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357971/
https://www.ncbi.nlm.nih.gov/pubmed/34381136
http://dx.doi.org/10.1038/s41598-021-95895-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357971/
https://www.ncbi.nlm.nih.gov/pubmed/34381136
http://dx.doi.org/10.1038/s41598-021-95895-7

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