USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade

Oncogenic activation of KRAS and its surrogates is essential for tumour cell proliferation and survival, as well as for the development of protumourigenic microenvironments. Here, we show that the deubiquitinase USP12 is commonly downregulated in the Kras(G12D)-driven mouse lung tumour and human non...

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Detalles Bibliográficos
Autores principales: Yang, Zhaojuan, Xu, Guiqin, Wang, Boshi, Liu, Yun, Zhang, Li, Jing, Tiantian, Tang, Ming, Xu, Xiaoli, Jiao, Kun, Xiang, Lvzhu, Fu, Yujie, Tang, Daoqiang, Zhang, Xiaoren, Jin, Weilin, Zhuang, Guanglei, Zhao, Xiaojing, Liu, Yongzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357983/
https://www.ncbi.nlm.nih.gov/pubmed/34381028
http://dx.doi.org/10.1038/s41467-021-25032-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357983/
https://www.ncbi.nlm.nih.gov/pubmed/34381028
http://dx.doi.org/10.1038/s41467-021-25032-5

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