Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

Lipid Nanoparticles (LNPs) are used to deliver siRNA and COVID-19 mRNA vaccines. The main factor known to determine their delivery efficiency is the pKa of the LNP containing an ionizable lipid. Herein, we report a method that can predict the LNP pKa from the structure of the ionizable lipid. We use...

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Detalles Bibliográficos
Autores principales: Carrasco, Manuel J., Alishetty, Suman, Alameh, Mohamad-Gabriel, Said, Hooda, Wright, Lacey, Paige, Mikell, Soliman, Ousamah, Weissman, Drew, Cleveland, Thomas E., Grishaev, Alexander, Buschmann, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358000/
https://www.ncbi.nlm.nih.gov/pubmed/34381159
http://dx.doi.org/10.1038/s42003-021-02441-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358000/
https://www.ncbi.nlm.nih.gov/pubmed/34381159
http://dx.doi.org/10.1038/s42003-021-02441-2

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