The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals

Circulating phosphate levels are tightly controlled within a narrow range in mammals. By using a novel small-molecule inhibitor, we show that the enzymatic activity of inositol hexakisphosphate kinases (IP6K) is essential for phosphate regulation in vivo. IP6K inhibition suppressed XPR1, a phosphate...

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Detalles Bibliográficos
Autores principales: Moritoh, Yusuke, Abe, Shin-ichi, Akiyama, Hiroki, Kobayashi, Akihiro, Koyama, Ryokichi, Hara, Ryoma, Kasai, Shizuo, Watanabe, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358040/
https://www.ncbi.nlm.nih.gov/pubmed/34381031
http://dx.doi.org/10.1038/s41467-021-24934-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358040/
https://www.ncbi.nlm.nih.gov/pubmed/34381031
http://dx.doi.org/10.1038/s41467-021-24934-8

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