N-Terminally Truncated and Pyroglutamate-Modified Aβ Forms Are Measurable in Human Cerebrospinal Fluid and Are Potential Markers of Disease Progression in Alzheimer’s Disease

Alzheimer’s disease (AD) is a pathology characterized by the accumulation in the brain of intracellular and extracellular amyloid-β (Aβ) aggregates, especially of Aβ1–40 and Aβ1–42 peptides. It is known that N-terminally truncated or modified Aβ forms also exist in AD brains and cerebrospinal fluid...

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Detalles Bibliográficos
Autores principales: Domingo, Guido, Benussi, Luisa, Saraceno, Claudia, Bertuzzi, Michela, Nicsanu, Roland, Longobardi, Antonio, Bellini, Sonia, Cagnotto, Alfredo, Salmona, Mario, Binetti, Giuliano, Ghidoni, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358181/
https://www.ncbi.nlm.nih.gov/pubmed/34393717
http://dx.doi.org/10.3389/fnins.2021.708119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358181/
https://www.ncbi.nlm.nih.gov/pubmed/34393717
http://dx.doi.org/10.3389/fnins.2021.708119

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