Fingolimod attenuates renal ischemia/reperfusion-induced acute lung injury by inhibiting inflammation and apoptosis and modulating S1P metabolism

OBJECTIVE: This study examined whether the immunomodulator fingolimod (FTY720) could alleviate renal ischemia/reperfusion (I/R)-induced lung injury and explored the potential mechanisms. METHODS: Renal I/R was established in a rat model, and FTY720 (0.5, 1, or 2 mg/kg) was injected intraperitoneally...

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Detalles Bibliográficos
Autores principales: Shi, Zu-an, Li, Ting-ting, Kang, Dao-ling, Su, Hang, Tu, Fa-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Pre-Clinical Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358582/
https://www.ncbi.nlm.nih.gov/pubmed/34340580
http://dx.doi.org/10.1177/03000605211032806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358582/
https://www.ncbi.nlm.nih.gov/pubmed/34340580
http://dx.doi.org/10.1177/03000605211032806

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