Tofacitinib Ameliorates Lupus Through Suppression of T Cell Activation Mediated by TGF-Beta Type I Receptor

Autoreactive T cells play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE). TGF-β type I receptor (TGFβRI) is pivotal in determining T cell activation. Here, we showed that TGFβRI expression in naïve CD4(+) T cells was decreased in SLE patients, especially in those with high...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Qing, Chen, Weiwei, Song, Hua, Long, Xianming, Zhang, Zhuoya, Tang, Xiaojun, Chen, Hongwei, Lin, He, Sun, Lingyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358742/
https://www.ncbi.nlm.nih.gov/pubmed/34394075
http://dx.doi.org/10.3389/fimmu.2021.675542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358742/
https://www.ncbi.nlm.nih.gov/pubmed/34394075
http://dx.doi.org/10.3389/fimmu.2021.675542

Ejemplares similares