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Tofacitinib Ameliorates Lupus Through Suppression of T Cell Activation Mediated by TGF-Beta Type I Receptor

Autoreactive T cells play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE). TGF-β type I receptor (TGFβRI) is pivotal in determining T cell activation. Here, we showed that TGFβRI expression in naïve CD4(+) T cells was decreased in SLE patients, especially in those with high...

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Detalles Bibliográficos
Autores principales:	Yan, Qing, Chen, Weiwei, Song, Hua, Long, Xianming, Zhang, Zhuoya, Tang, Xiaojun, Chen, Hongwei, Lin, He, Sun, Lingyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358742/ https://www.ncbi.nlm.nih.gov/pubmed/34394075 http://dx.doi.org/10.3389/fimmu.2021.675542

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