Cargando…
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPKα/TGF‐β/Smad signalling in type 2 diabetic rats
Diabetic cardiomyopathy (DCM) is one of the leading causes of heart failure in patients with diabetes mellitus, with limited effective treatments. The cardioprotective effects of sodium‐glucose cotransporter 2(SGLT2) inhibitors have been supported by amounts of clinical trials, which largely fills t...
Autores principales: | Tian, Jingjing, Zhang, Mingjun, Suo, Mengying, Liu, Dian, Wang, Xuyang, Liu, Ming, Pan, Jinyu, Jin, Tao, An, Fengshuang |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358881/ https://www.ncbi.nlm.nih.gov/pubmed/34169635 http://dx.doi.org/10.1111/jcmm.16601 |
Ejemplares similares
-
The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats
por: Gong, Lei, et al.
Publicado: (2020) -
SIRT1 mediates the inhibitory effect of Dapagliflozin on EndMT by inhibiting the acetylation of endothelium Notch1
por: Wang, Weijie, et al.
Publicado: (2023) -
Nicorandil alleviates apoptosis in diabetic cardiomyopathy through PI3K/Akt pathway
por: Wang, Xuyang, et al.
Publicado: (2019) -
KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway
por: Xu, Hongyuan, et al.
Publicado: (2022) -
WISP1 alleviates lipid deposition in macrophages via the PPARγ/CD36 pathway in the plaque formation of atherosclerosis
por: Liu, Dian, et al.
Publicado: (2020)