Ring Distortion of Vincamine Leads to the Identification of Re-Engineered Antiplasmodial Agents

[Image: see text] There is a significant need for new agents to combat malaria, which resulted in ∼409,000 deaths globally in 2019. We utilized a ring distortion strategy to create complex and diverse compounds from vincamine with the goal of discovering molecules with re-engineered biological activ...

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Detalles Bibliográficos
Autores principales: Norwood, Verrill M., Murillo-Solano, Claribel, Goertzen, Michael G., Brummel, Beau R., Perry, David L., Rocca, James R., Chakrabarti, Debopam, Huigens, Robert William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359148/
https://www.ncbi.nlm.nih.gov/pubmed/34395993
http://dx.doi.org/10.1021/acsomega.1c02480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359148/
https://www.ncbi.nlm.nih.gov/pubmed/34395993
http://dx.doi.org/10.1021/acsomega.1c02480

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