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Ring Distortion of Vincamine Leads to the Identification of Re-Engineered Antiplasmodial Agents
[Image: see text] There is a significant need for new agents to combat malaria, which resulted in ∼409,000 deaths globally in 2019. We utilized a ring distortion strategy to create complex and diverse compounds from vincamine with the goal of discovering molecules with re-engineered biological activ...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359148/ https://www.ncbi.nlm.nih.gov/pubmed/34395993 http://dx.doi.org/10.1021/acsomega.1c02480 |