RAPGEF2 mediates oligomeric Aβ‐induced synaptic loss and cognitive dysfunction in the 3xTg‐AD mouse model of Alzheimer’s disease

AIMS: Amyloid‐β (Aβ) oligomers trigger synaptic degeneration that precedes plaque and tangle pathology. However, the signalling molecules that link Aβ oligomers to synaptic pathology remain unclear. Here, we addressed the potential role of RAPGEF2 as a novel signalling molecule in Aβ oligomer‐induce...

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Detalles Bibliográficos
Autores principales: Jang, You‐Na, Jang, HoChung, Kim, Gyu Hyun, Noh, Jeong‐Eun, Chang, Keun‐A, Lee, Kea Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359155/
https://www.ncbi.nlm.nih.gov/pubmed/33345400
http://dx.doi.org/10.1111/nan.12686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359155/
https://www.ncbi.nlm.nih.gov/pubmed/33345400
http://dx.doi.org/10.1111/nan.12686

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