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The Drug Titration Paradox: Correlation of More Drug With Less Effect in Clinical Data
While analyzing clinical data where an anesthetic was titrated based on an objective measure of drug effect, we observed paradoxically that greater effect was associated with lesser dose. With this study we sought to find a mathematical explanation for this negative correlation between dose and effe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359232/ https://www.ncbi.nlm.nih.gov/pubmed/33426670 http://dx.doi.org/10.1002/cpt.2162 |