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The Drug Titration Paradox: Correlation of More Drug With Less Effect in Clinical Data

While analyzing clinical data where an anesthetic was titrated based on an objective measure of drug effect, we observed paradoxically that greater effect was associated with lesser dose. With this study we sought to find a mathematical explanation for this negative correlation between dose and effe...

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Detalles Bibliográficos
Autores principales: Schnider, Thomas W., Minto, Charles F., Filipovic, Miodrag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359232/
https://www.ncbi.nlm.nih.gov/pubmed/33426670
http://dx.doi.org/10.1002/cpt.2162

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