Safety, Tolerability, and Pharmacokinetics of Multiple Repeated Oral Doses of the α2/3/5‐Subtype Selective GABA(A)‐Positive Allosteric Modulator PF‐06372865 in Healthy Volunteers

Multiple‐dose pharmacokinetics (PK) and safety were investigated in this phase 1 study of PF‐06372865, a positive allosteric modulator of α2/3/5 subunit‐containing γ‐aminobutyric acid A receptors (NCT03351751). In 2 cohorts (7‐8 PF‐06372865 and 2 placebo in each cohort), healthy adult subjects recei...

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Detalles Bibliográficos
Autores principales: Gurrell, Rachel, Whitlock, Mark, Wei, Hua, Shen, Zhongzhou, Ogden, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359322/
https://www.ncbi.nlm.nih.gov/pubmed/33465277
http://dx.doi.org/10.1002/cpdd.912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359322/
https://www.ncbi.nlm.nih.gov/pubmed/33465277
http://dx.doi.org/10.1002/cpdd.912

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