Evaluation of drug interaction potential of zanubrutinib with cocktail probes representative of CYP3A4, CYP2C9, CYP2C19, P‐gp and BCRP

AIM: This study aims to assess the potential effects of zanubrutinib on the activity of cytochrome P450 (CYP) enzymes and drug transporter proteins using a cocktail probe approach. METHODS: Patients received single oral doses of probe drugs alone and after at least 8 days of treatment with zanubruti...

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Detalles Bibliográficos
Autores principales: Ou, Ying C., Tang, Zhiyu, Novotny, William, Tawashi, Manal, Li, Ta‐Kai, Coleman, Hugh A., Sahasranaman, Srikumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359458/
https://www.ncbi.nlm.nih.gov/pubmed/33336408
http://dx.doi.org/10.1111/bcp.14707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359458/
https://www.ncbi.nlm.nih.gov/pubmed/33336408
http://dx.doi.org/10.1111/bcp.14707

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