Histone deacetylase inhibition leads to regulatory histone mark alterations and impairs meiosis in oocytes

BACKGROUND: Panobinostat (PB), a histone deacetylase (HDAC) inhibitor drug, is clinically used in the treatment of cancers. We investigated the effects of PB on murine ovarian functions in embryos and adult animals. METHODS: C57BL/6J mice were treated with 5 mg/kg PB on alternate days from embryonic...

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Detalles Bibliográficos
Autores principales: Legoff, Louis, Dali, Ouzna, De La Mata Santaella, Elena, Jaulin, Christian, D’Cruz, Shereen Cynthia, Smagulova, Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359552/
https://www.ncbi.nlm.nih.gov/pubmed/34384478
http://dx.doi.org/10.1186/s13072-021-00413-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359552/
https://www.ncbi.nlm.nih.gov/pubmed/34384478
http://dx.doi.org/10.1186/s13072-021-00413-8

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