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Histone deacetylase inhibition leads to regulatory histone mark alterations and impairs meiosis in oocytes
BACKGROUND: Panobinostat (PB), a histone deacetylase (HDAC) inhibitor drug, is clinically used in the treatment of cancers. We investigated the effects of PB on murine ovarian functions in embryos and adult animals. METHODS: C57BL/6J mice were treated with 5 mg/kg PB on alternate days from embryonic...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359552/ https://www.ncbi.nlm.nih.gov/pubmed/34384478 http://dx.doi.org/10.1186/s13072-021-00413-8 |