Designing of the N-ethyl-4-(pyridin-4-yl)benzamide based potent ROCK1 inhibitors using docking, molecular dynamics, and 3D-QSAR

Rho-associated kinase-1 (ROCK1) has been recognized for its pivotal role in heart diseases, different types of malignancy, and many neurological disorders. Hyperactivity of ROCK phosphorylates the protein kinase-C (PKC), which ultimately induces smooth muscle cell contraction in the vascular system....

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Detalles Bibliográficos
Autores principales: Ghosh, Suparna, Keretsu, Seketoulie, Cho, Seung Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359802/
https://www.ncbi.nlm.nih.gov/pubmed/34434664
http://dx.doi.org/10.7717/peerj.11951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359802/
https://www.ncbi.nlm.nih.gov/pubmed/34434664
http://dx.doi.org/10.7717/peerj.11951

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